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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Dec 23;48:122–130. doi: 10.1016/j.conb.2017.12.003

Figure 4.

Figure 4

Schematic representation of our working model for cell type–specific changes in NLGN1 and NLGN2 after IA training and retrieval-induced memory strengthening in the PL cortex. IA training may increase NLGN2 expression in parvalbumin-positive interneurons (PV+), which would lead to disinhibition of pyramidal (Pyr) cells, as well as NLGN1 in Pyr cells. These changes would result in increased E/I. Memory retrieval-induced strengthening would decrease NLGN2 levels in Pyr cells, while maintaining NLGN2 increased levels in PV+ neurons. These changes would further increase excitation. Together, these NLGN1 and NLGN2 changes on different neuronal populations would differentially regulate E/I balance in memory consolidation and following retrievals leading to memory strengthening.