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. Author manuscript; available in PMC: 2019 Feb 28.
Published in final edited form as: J Control Release. 2018 Jan 3;272:9–16. doi: 10.1016/j.jconrel.2017.12.032

Figure 5.

Figure 5

Quantitative image analysis of 35 nm AuNPs in the tumors of control or JO-4 pretreated mice. (a) Number of AuNPs detected per image. (b, c) Boxplots of the fraction (b) and total number (c) of AuNPs penetrating beyond given threshold distances from a blood vessel. ● indicates the mean of the data. n = 6 or 7 tumor sections pooled from 3 mice, data aggregated from 11 images per section. Statistical significance was assessed using a nonparametric (assuming nonnormal distributions) two-tailed Mann-Whitney test for (a) and two-tailed t-tests for (b) and (c). **p < 0.01, ***p < 0.001, ****p < 0.0001