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. 2018 Feb 12;175(6):924–937. doi: 10.1111/bph.14134

Figure 2.

Figure 2

Activation of human and rat ASIC3 channels by LIN. Whole‐cell currents recorded from (A, B) human or (C, D) rat ASIC3 channels in response to the (A, C) pH 5.5 stimulus or to (B, D) 1 mM LIN application at the constant pH 7.8. Single‐exponential fitting of current recovery after termination of LIN application gave the τ off time constants of 4.42 ± 0.02 s (0.1 mM LIN), 6.61 ± 0.04 s (0.3 mM LIN) and 11.13 ± 0.07 s (1 mM LIN) for hASIC3 and 2.7 ± 0.2 s (0.1 mM LIN), 2.48 ± 0.09 s (0.3 mM LIN) and 2.02 ± 0.02 s (1 mM LIN) for rASIC3. (E) Dose–response curves for hASIC3 and rASIC3 activation by LIN. Data presented are mean ± SEM (n = 5). Solid lines through the points fit with the logistic equation. (F) Amplitude of 1 mM LIN‐induced hASIC3 current measured at pH 7.4, 7.8 and 8.5. Data shown are mean ± SEM; n = 5. *P < 0.05, significantly different from current amplitudes at pH 7.8; Kruskal–Wallis ANOVA.