Table 1.

List of genes predicted with the individual fold-change analysis

Rank	Gene	Correlation	Known role from the literature
1	Rffl	−0.446656	Hypertension57
2	Wdr1	0.415692	Cardiac Hypertrophy58
3	Nppb	0.408886	Heart failure marker59
4	Atp6v0a1	0.407205	Hypertension60
5	Ankrd1	0.406246	Dilated cardiomyopathy61
6	Eif4a1	0.404824
7	Dtr (HB-EGF)	0.403043	Heart failure62
8	Kcnip2	0.402246	Downregulated in hypertrophy23,24,26
9	Pcdhgc4	−0.402053
10	Hes1	0.400076	Heart outflow tract development.63 Validation in the present study.
11	4930504E06Rik	0.396189
12	Akap9	−0.389713	LQT syndrome64
13	2310022B05Rik	0.3897
14	Bclaf1	−0.388563
15	Ttc13	−0.387981
16	Nipsnap3b	0.387325
17	Gss	0.386407	Glutathione synthetase, linked to cardiac abnormalities65–67
18	Klhl23	−0.385625
19	Tspan17	0.384865
20	Tnni2	−0.383516
21	Cab39l	−0.381902
22	Ptrf (Cavin-1)	0.381134	Dilated cardiomyopathy68
23	Dedd	0.378059
24	9430041O17Rik	0.375683
25	Fgf16	0.373829	Heart disease69
26	Ehd2	0.372787	Regulate cardiac membrane protein targeting.70 Interact with ankyrin-B (ANK2 gene whose mutation is associated with hypertrophic cardiomyopathy71)
27	Ppp1r9a	−0.372641	Subunit of the same complex than PPP1R3A, involved in HF in human patients51
28	Kremen	0.372366	Interacts with Wnt signaling72
			Wnt signaling also plays a role in cardiac hypertrophy73
29	Scara5	−0.372294
30	Zfp523	−0.372223
31	Nfatc1	0.371409	Cardiac hypertrophy34
32	Corin	−0.369546	Cardiac protease that regulates blood pressure by activating natriuretic peptides, involved in cardiac hypertrophy74
33	Prnpip1	0.369466
34	Lrrc1	0.369161
35	AW549877	−0.368865
36	Mkrn3	−0.368269