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. 2018 Jan 1;145(1):dev159905. doi: 10.1242/dev.159905

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 8. — Multiphasic function of intersection of canonical and non-canonical Wnt signaling during cardiovascular lineage diversification. Wnt plays multiple roles during differentiation of pluripotent cells within the cardiovascular lineage. Wnt signaling initially directs pluripotent cells toward cardiac mesoderm, but is later inhibited during specification of cardiac progenitor cells expressing Nkx2.5. Subsequently, inhibition of Wnt signaling within the Nkx2.5⁺ pool via non-canonical Wnt5a promotes vascular specification.