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. 2018 Jan 1;145(1):dev155838. doi: 10.1242/dev.155838

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Evidence of progressive lens fibre cell differentiation in ROR1⁺ cell aggregates. Electron microscopy data from cultured aggregates. (A,B) A micro-lens cultured for 14 days shows a monolayer of LEC-like cells at the periphery of the tissue (A), and cells with small, rod-shaped nuclei (asterisk) and numerous organelles within the bulk of the tissue (B). (C) LEC-like cell with numerous organelles present at the periphery of a micro-lens after 24 days of culture. (D-G) Ultrastructural indicators of lens fibre cell differentiation within a micro-lens cultured for 42 days. (D) Ball-and-socket type membrane interdigitations (arrows) between adjacent lens fibre-like cells (inset shows a higher magnification of the region indicated with an arrow and asterisk). (E) A swollen mitochondria (arrow). (F) An enlarged nuclei with spoke-like nucleolus (inset). (G) A degraded nuclei with nuclear membrane visible as a series of vesicles (arrowheads). Scale bars: 5 µm in A-C; 2 µm in D,F,G; 0.5 µm in E. Images are representative of seven micro-lenses obtained from two biological replicates.