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. 2018 Jan 1;145(1):dev156588. doi: 10.1242/dev.156588

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Mice homozygous for the recombined Trip11 conditional allele (Trip11⁻) have a severe skeletal dysplasia. (A) E17.5 wild-type (Trip11^+/+) and recombined (Trip11^−/−) embryos. Note the short limbs, short snout, domed skull, protruding tongue and omphalocele in the recombined (i.e. knockout) embryo. (B-G) Skeletal preparations of the embryos shown in A. Compared with the Trip11^+/+ embryo, the Trip11^−/− embryo has: (B) a smaller ribcage; (C) decreased mineralization of the calvarium (arrow); (D) absent mineralization of the sternum (arrow); (E) absent mineralization of the vertebral bodies (arrow); (F) short forelimbs; and (G) short hindlimbs. n=3; one representative result is shown.