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. 2018 Feb 19;9:247. doi: 10.3389/fimmu.2018.00247

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Copyright © 2018 Guo, Xu, Zhou, Zhou, Wang, Li, Liu, Liu, Zhang and Ho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Toll-like receptor 3 signaling induces interferon (IFN)-β and IFN-λ expression. (A) Intestinal epithelial cells (IECs) were transfected with Poly I:C (1 µg/ml) for the indicated times. Dose-dependent effect of Poly I:C on IFN induction of IECs at (B) mRNA and (C) protein levels. Data shown were the mean ± SD of three independent experiments. Asterisks indicate that the differences between the indicated groups are statistically significant (**P < 0.01).