. 2018 Feb 3;5(2):ofy032. doi: 10.1093/ofid/ofy032

Table 3.

Univariable and Multivariable Linear Regression Analysis of Factors Associated With Mean Differences in Levels of Residual Plasma HIV-1 RNA (n = 102)^a

	Univariate			Multivariable^c
	Mean Difference^b	95% CI	P	Mean Difference	95% CI	P
Nadir CD4 count per 100 cell/mm³ higher	0.01	–0.06 to 0.05	.58
Pre-ART viral load per log₁₀ cps/mL higher	0.00	–0.08 to 0.08	.99
Duration of suppressive ART per 1 y longer	–0.01	–0.03 to 0.00	.12	–0.01	–0.02 to 0.01	.39
CD4 count per 100 cells/mm³ higher	–0.01	–0.02 to 0.02	.92
CD4/CD8 ratio per 1 unit higher	0.04	–0.11 to 0.17	.62
2-LTRc DNA per log₁₀ cps/10⁶ PBMC higher	0.05	–0.11 to 0.20	.57
Total HIV-1 DNA per log₁₀ cps/10⁶ PBMC higher	–0.01	–0.09 to 0.08	.87
CD4⁺CD38⁺ per 50% higher	0.08	–0.14 to 0.30	.47
CD4⁺CD26⁺ per 50% higher	0.08	–0.10 to 0.27	.37
CD4⁺CD69⁺ per 50% higher	–0.61	–2.97 to 1.75	.60
CD8 count per 100 cells/mm³ higher	0.02	–0.01 to 0.01	.70
CD8⁺CD38⁺ per 50% higher	0.32	–0.11 to 0.75	.16	0.26	–0.17 to 0.68	.24
CD8⁺HLA-DR/DP/DQ⁺ per 50% higher	–0.03	–0.21 to 0.15	.76
sCD14 per log₁₀ µg /mL higher	0.26	–0.24 to 0.75	.31
sCD27 per log₁₀ U/mL higher	0.49	0.17 to 0.81	.003	0.37	0.01 to 0.73	.02
sCD30 per log₁₀ ng/mL higher	0.21	–0.02 to 0.45	.07	0.02	–0.25 to 0.28	.88
IL6 per log₁₀ pg/mL higher	0.13	–0.05 to 0.30	.15	0.12	–0.06 to 0.29	.19

Abbreviations: 2-LTRc DNA, 2-LTR circular HIV-1 DNA; ART, antiretroviral therapy; CI, confidence interval; cps, copies; PBMC, peripheral blood mononuclear cell.

^aThe analysis excluded the 2 outliers with residual plasma HIV-1 RNA >11 copies/mL.

^bMean difference in log₁₀ copies/mL.

^cVariables with P < .2 in the univariable analysis were included in the multivariable analysis.