Table 3.
Rheological studies of formulation and characterization of the prepared gels
| Formulation | Before gelation
|
After gelation
|
||||
|---|---|---|---|---|---|---|
| Viscosity of solution (mPa s) | Viscosity of in situ gel (mPa s) | Appearance | pH | Gelling capacity | % drug content | |
| Gel A | 200 | 480 | Transparent solution | 6.54 | + | 85.2 |
| Gel B | 500 | 2,200 | Transparent solution | 6.32 | +++ | 84.8 |
| Gel C | 6,000 | 8,000 | Transparent solution | 6.06 | ++++ | 86.2 |
Notes: +Gelation occurred in few minutes (5 min) and remained for few hours (1 h); +++gelation immediate (30 s), and for extended period (permanent); ++++very stiff gel (gel formation immediately and permanently).