. 2018 Feb 20;17:1533033818758772. doi: 10.1177/1533033818758772

Table 4.

Associations Between Clinical Characteristics and the Expression of mTOR Signaling Pathway Proteins.

Factors	N	PTEN Expression			mTOR Expression			p-mTOR Expression			P70S6K1 Expression
Factors	N	Low	High	P	Low	High	P	Low	High	P	Low	High	P
Age, years				.198			.788			.989			.888
≤60	78	49	29		39	39		36	42		41	37
>60	67	35	32		35	32		31	36		36	31
Sex				.360			.518			.025			.420
Male	111	62	49		55	56		57	54		61	50
Female	34	22	12		19	15		10	24		16	18
Tumor length				.185			.447			.008			.005
<3 cm	37	18	19		23	14		24	13		27	10
≥3 cm	108	66	42		51	57		43	65		50	58
Differentiation				.100			.282			.059			.160
Well	17	9	8		10	7		9	8		12	5
Moderately	90	54	36		52	38		47	43		44	46
Poorly	38	21	17		12	26		11	27		21	17
T stage				.001			.308			.422			.003
T1	13	4	9		9	4		8	5		9	4
T2	34	12	22		16	18		18	16		23	11
T3	64	42	22		35	29		26	38		40	24
T4	34	26	8		14	20		15	19		10	24
N stage				.003			.026			.002			.000
N0	55	24	31		35	20		36	19		39	16
N1	55	31	24		28	27		22	33		31	24
N2	30	25	5		9	21		8	22		4	26
N3	5	4	1		2	3		1	4		3	2
TNM stage				.017			.022			.010			.028
I	12	3	9		9	3		8	4		10	2
II	53	28	25		32	21		31	22		31	22
III + IV	80	53	27		33	47		28	52		36	44
PTEN							.085						.000
Low	84	–	–	–	48	36		–	–	–	25	59
High	61	–	–		26	35		–	–		52	9
p-AKT				.000			.036			.071			.000
Low	77	36	41		33	44		41	36		52	25
High	68	48	20		41	27		26	42		25	43
p-mTOR				.544			.000						.601
Low	67	37	30		45	22		–	–	–	34	33
High	78	47	31		29	49		–	–		43	35
p-4E-BP1				.088			.056			.992			.000
Low	93	49	44		53	40		43	50		61	32
High	52	35	17		21	31		24	28		16	36
p-P70S6K1				.019			.167			.272			.000
Low	86	43	43		48	38		43	43		57	29
High	59	41	18		26	33		24	35		20	39

Abbreviations: mTOR, mammalian target of rapamycin; P70S6K1, P70S6 kinase 1; PTEN, phosphatase and tensin homolog. Bold values mean significant difference.