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. 2018 Feb 22;8(2):2045894018759125. doi: 10.1177/2045894018759125

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© The Author(s) 2018

Creative Commons CC-BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 1. — Serotonin is synthesized from L-tryptophan through the activity of TPH which converts L-tryptophan to 5-HT. This is converted to serotonin by 5-hydroxytryptophandecarboxylase and aromatic L-amino acid decarboxylase. Serotonin is metabolized to 5-HIAA via MAO and aldehyde dehydrogenase.