Table 1.

The biologic adverse reaction between ionic and non-ionic contrast media.

Biologic adverse reaction	Ionic contrast media	Non-ionic contrast media
Thermal effect	Moderate	Mild to less
Pain during injection	Moderate	Mild to less
Nausea and vomiting	Moderate	Mild to less
Toxicity to kidney	Higher	Lower
Tissue necrosis when extravasation occurs	More severe	Less severe
Other allergic effects	Often (around 10%)	Seldom (lower than 5%)