Table 2.

Effect of tumor-derived exosomes in endothelial cell (EC) biology.

Process	Exosomal factor	Effect	References
Angiogenesis	miR-92a and CO-029/D6.1A Tetraspanin	EC tube formation	Gesierich et al., 2006; Umezu et al., 2013
	Syndecan-1, Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor	EC invasion	Thompson et al., 2013
	Epidermal Growth Factor Receptor (EGFR) and miR-9	Angiogenesis	Al-Nedawi et al., 2009; Gajos-Michniewicz et al., 2014
	MMP9, Pentraxin 3, IL-8, PDGF-AB/AA, CD26, Plasminogen Activator Inhibitor 1, Caveolin 1, Tissue Factor, Factor VIIa, Wnt4, miR-210, miR-23a	ECs proliferation and angiogenesis	Svensson et al., 2011; King et al., 2012; Kucharzewska et al., 2013; Huang and Feng, 2017; Sruthi et al., 2017
Integrity of vascular barriers	miR-105	Destruction of endothelial barriers and promotion of metastasis	Zhou W. et al., 2014
	miR-181c	Breakdown of blood-brain barrier	Tominaga et al., 2015
	VEGF-A	Increase in ECs permeability and angiogenesis	Treps et al., 2017