TABLE 2.
Treatment outcome predictors for the enrolled patientsa
| Factor | No. of patients |
Odds ratio (95% confidence interval) | P value | |
|---|---|---|---|---|
| Total | With favorable outcome | |||
| Age (yr) | ||||
| ≤20 | 3 | 0 | NA | 0.491 |
| >20–≤40 | 9 | 4 | 1 | |
| >40–<60 | 14 | 7 | 1.250 (0.233–6.715) | 1.000 |
| ≥60 | 1 | 0 | NA | 1.000 |
| Gender | ||||
| Male | 21 | 7 | 1 | |
| Female | 6 | 4 | 4.000 (0.584–27.411) | 0.187 |
| Drug resistance pattern | ||||
| Simple MDR | 6 | 4 | 1 | |
| Pre-XDR | 12 | 5 | 0.357 (0.046–2.771) | 0.620 |
| XDR | 9 | 2 | 0.143 (0.014–1.444) | 0.136 |
| Dosage (mg/day) | ||||
| 500 | 23 | 8 | 1 | |
| 750 | 4 | 3 | 5.625 (0.500–63.282) | 0.273 |
| MIC (μg/ml) | ||||
| <32 | 22 | 11 | 1 | |
| ≥32 | 5 | 0 | NA | 0.06 |
| Cmax (μg/ml) | ||||
| ≤20 | 11 | 3 | 0.429 (0.081–2.277) | 0.428 |
| >20–<35 | 15 | 7 | 1 | |
| ≥35 | 1 | 1 | NA | 1.00 |
| Cmax/MIC | ||||
| <1 | 15 | 3 | 1 | 0.022 |
| ≥1 | 12 | 8 | 8.000 (1.399–45.756) | |
a
Cmax, serum concentration after 2 h; NA, not applicable.