FIG 6.

Conformation of the M509 residue in the wild-type and ScErg11p6×His G73W apo structures. The surface cutaway of the ScErg11p6×His G73W apo structure (PDB accession number 5ESI) (cyan) shows the altered substrate channel due to a different conformation of the M509 residue. The G73W mutant structure was aligned to the structure of wild-type ScErg11p6×His in complex with the FLC structure (PDB accession number 4WMZ) (inset). The M509 and S508 residues are shown as sticks, with C atoms in cyan in the G73W apo substrate channel and in yellow in the wild-type FLC structure.