TABLE 1.

Combination of disc test, proteomics, WGS, and predictions of fluoroquinolone susceptibility for K. pneumoniae clinical isolates^a

^aSusceptibilities (S, susceptible; NS, nonsusceptible) were defined by reference to zone diameters that were the means from three repetitions rounded to the nearest integer. Zones with dark shading are nonsusceptible according to susceptibility breakpoints set by the CLSI (32). Predictions with medium and light shading show successes and failures, respectively, in predicting fluoroquinolone susceptibility by using the preliminary rules (see Table S5 in the supplemental material). CIP, ciprofloxacin; LEV, levofloxacin; NOR, norfloxacin; OFL, ofloxacin; +, the gene is present; −, mutations were not detected or the gene is absent; ND, protein was not detected.

^bChanges in amino acids not associated with changes in gene function, likely due to genetic drift.