TABLE 1.
Synergistic activity of combinations of fluconazole and sulfonamide antibacterial drugs against different resistant strains of Candida albicans isolates
| Sulfa drug | MIC50 (μg/ml)a |
FIC index | Interpretationc | |||
|---|---|---|---|---|---|---|
| FLC |
Sulfa drug |
|||||
| Alone | In combination (MICc)b | Alone | In combination (MICc) | |||
| 4-Amino phenyl sulfone (dapsone) | 512 | 1 | 512 | 32 | 0.0625 | SYN |
| Sulfadiazine | 512 | 0.5 | 512 | 32 | 0.0625 | SYN |
| Sulfamethazine | 1,024 | 1 | 1024 | 128 | 0.125 | SYN |
| Sulfamethoxazole | 512 | 1 | 512 | 16 | 0.0312 | SYN |
| Sulfanilamide | >1,024 | >128 | >1,024 | >1,024 | 2 | IND |
| Sulfacetamide | >1,024 | >128 | >1,024 | >1,024 | 2 | IND |
| Sulfabenzimide | >1,024 | >128 | >1,024 | >1,024 | 2 | IND |
| Sulfadoxine | 512 | 1 | 512 | 64 | 0.125 | SYN |
| Sulfanitran | >1,024 | >128 | >1,024 | >1,024 | 2 | IND |
| Sulfamerazine | 1,024 | 0.5 | 1,024 | 128 | 0.125 | SYN |
| Sulfamonomethoxine | 512 | 0.5 | 512 | 16 | 0.0312 | SYN |
| Sulfadimethoxine | 1,024 | 0.5 | 1,024 | 64 | 0.0625 | SYN |
| Succinylsulfathiazole | >1,024 | >128 | >1,024 | >1,024 | 2 | IND |
| Sulfathiazole | 1,024 | 0.5 | 1,024 | 128 | 0.125 | SYN |
| Sulfaguanidine | >1,024 | >128 | >1,024 | >1,024 | 2 | IND |
| Sulfapyridine | 512 | 1 | 512 | 64 | 0.125 | SYN |
| Sulfametopyrazine (sulfalene) | 1,024 | 0.5 | 1,024 | 64 | 0.0625 | SYN |
| Sulfametoxydiazine (sulfameter) | 512 | 0.5 | 512 | 64 | 0.125 | SYN |
| Sulfisomidine | 1,024 | 0.5 | 1,024 | 128 | 0.125 | SYN |
| Sulfisoxazole (sulfafurazole) | 1,024 | 1 | 1,024 | 128 | 0.125 | SYN |
| Sulfamethoxypyridazine | 512 | 1 | 512 | 32 | 0.0625 | SYN |
a
MIC50 is the lowest concentration of the drug that showed at least 80% reduction of the growth of 50% of the tested Candida strains.
b
MICc is the MIC of the drug when used in combination with fluconazole.
c
FIC index interpretations: ≤0.5, synergism (SYN); >0.5 to 4, indifferent (IND); >4, antagonism.