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Median values for urine pharmacokinetic parameters for meropenem, stratified by groupa
| Renal study group | Median value for meropenem in urine (range) |
||
|---|---|---|---|
| Amt excreted over 48 h (mg) | % of dose excreted over 48 h | Renal clearance (liters/h) | |
| Normal (n = 8) | 647 (504–727) | 64.7 (50.4–72.7) | 7.19 (5.03–11.9) |
| Mild (n = 8) | 549 (438–724) | 54.9 (43.8–72.4) | 5.37 (2.58–9.58) |
| Moderate (n = 8) | 523 (491–651) | 52.3 (49.1–65.1) | 3.47 (1.90–5.00) |
| Severe (n = 8) | 339 (248–516) | 33.9 (24.8–51.6) | 0.876 (0.569–1.66) |
