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Pharmacokinetic parameters of levonadifloxacin in plasma following the first and ninth oral doses of 1,000 mg
| Dose no. | Mean ± SD |
|||||
|---|---|---|---|---|---|---|
| Cmax (mg/liter) | Tmax (h) | AUCa (mg · h/liter) | t1/2 (h) | V/F (liters) | CL/F (liters/h) | |
| 1 | 16.5 ± 5.1 | 1.8 ± 0.7 | 116.2 ± 28.7 | 4.5 ± 0.9 | 58.0 ± 14.7 | 9.11 ± 2.23 |
| 9 | 20.0 ± 4.3 | 2.1 ± 1.4 | 129.8 ± 31.6 | 5.1 ± 1.3 | 59.2 ± 16.0 | 8.17 ± 2.05 |
AUC for the first dose was AUC0–∞, and AUC for the ninth dose was AUC0–12.
