TABLE 1.
Baseline characteristics of the ITT population
| Parameter | No. of patients (%) | Value |
|---|---|---|
| Median age (yr) (IQR) | 72 | 6 (3–13) |
| <5 | 27 (37.5) | |
| 5–18 | 31 (43.1) | |
| >18 | 14 (19.4) | |
| Median wt (kg) (IQR) | 58a | 17.5 (13–26) |
| Mean overall BMI (SD) | 54 | 16.7 (13.2) |
| BMI adapted to sex and age | ||
| Severely underweight | 4 (7.4) | |
| Underweight | 4 (7.4) | |
| Normal wt | 34 (63) | |
| Overweight | 8 (14.8) | |
| Obese | 4 (7.4) | |
| Median asexual parasitemia (parasites/μl) (IQR) | 68b | 932 (334.3–4,126) |
| Mean hemoglobin (mmol/liter) (SD) | 62 | 6.1 (1.4) |
| Mean hematocrit (%) (SD) | 62 | 31.7 (6) |
| Mean systolic blood pressure (mm Hg) (SD) | 64 | 104.1 (16) |
| Mean diastolic blood pressure (mm Hg) (SD) | 64 | 69.4 (13.3) |
| Mean heart rate (beats/min) (SD) | 66 | 101.4 (21.8) |
a
Out of the values missing, the weights of 2 children were calculated with the following formula: weight = (2 × age) + 8; the other 12 missing weights were for adults and received an adult dose of artemether-lumefantrine.
b
For missing values only positivity and detection of non-P. falciparum species were documented.