TABLE 1.
Summary of microbiological activity of APX001A and comparators against 16 strains of C. auris
| Antifungal agent | Treatment period (h) | MIC (μg/ml)a |
||
|---|---|---|---|---|
| Range | MIC50 | MIC90 | ||
| APX001A | 24 | 0.002–0.063 | 0.004 | 0.031 |
| 5FC | 48 | 0.5–1 | 0.5 | 1 |
| AFG | 24 | 0.125–0.25 | 0.125 | 0.25 |
| CAS | 24 | 0.25–1 | 0.5 | 1 |
| MFG | 24 | 0.25–2 | 1 | 2 |
| AMB | 24 | 0.5–8 | 2 | 4 |
| 48 | 2–8 | 4 | 8 | |
| FLC | 24 | 1–>64 | 16 | >64 |
| 48 | 2–>64 | >64 | >64 | |
| ITC | 48 | <0.063–1 | 0.5 | 1 |
| POS | 48 | 0.25–1 | 0.25 | 1 |
| VRC | 24 | <0.063–1 | 0.5 | 1 |
| 48 | <0.063–2 | 0.5 | 2 | |
a
MIC values were read at either 50 or 100% inhibition as indicated by CLSI; APX001A was read at 50% inhibition and at 24 h as previously determined.