TABLE 1.
Antimicrobial activity in the presence and absence of ibuprofen over 12 h
| Isolate | No. of log CFU/ml after treatment with IBU at the following concn (μg/ml)a: |
|||
|---|---|---|---|---|
| 0 | 50 | 75 | 100 | |
| Pseudomonas aeruginosa PAO1 | 2.69E+09 | 7.63E+08* | 2.87E+08* | 1.08E+08* |
| Pseudomonas aeruginosa M57-15 | 4.38E+09 | 2.27E+09 | 6.37E+08* | 2.05E+08* |
| Pseudomonas aeruginosa T63547 | 7.91E+09 | 3.84E+09 | 5.59E+08* | 2.70E+08* |
| Pseudomonas aeruginosa H25815 | 1.93E+09 | 1.57E+09 | 3.85E+08* | 3.26E+07* |
| Burkholderia cenocepacia K56-2 | 1.24E+07 | 7.06E+06* | 3.40E+06* | 1.30E+05* |
| Burkholderia multivorans SH-2 | 7.18E+07 | 4.32E+07* | 8.71E+06* | 7.94E+05* |
| Burkholderia cepacia 1753 | 3.98E+07 | 1.61E+07* | 6.28E+06* | 6.74E+05* |
| Burkholderia cenocepacia HI4277 | 9.52E+06 | 6.46E+06 | 5.47E+05* | 4.95E+04* |
a
Controls for the experiment include uninoculated MH broth and MH broth with DMSO (5%, vol/vol) without ibuprofen (IBU; 0 μg/ml). The mean numbers of log CFU are from at least three replicate experiments performed in duplicate wells (at least 6 sample replicates per treatment and pathogen) and were analyzed using a two-tailed paired t test. *, significant differences compared to the control (P ≤ 0.05).