L-161,982 inhibits the growth of S. aureus strains. The antimicrobial activity of selective COX enzyme inhibitors or PGE2 EP receptor antagonists on the growth of C. albicans DAY185 (A), S. aureus NRS383 (B), and MRSA and MSSA clinical isolates (C) was determined. The growth of C. albicans and S. aureus in medium alone or in medium supplemented with DMSO, EP receptor antagonists, or COX enzyme inhibitors at physiologically relevant concentrations was monitored for up to 24 h. The data shown are representative of those from three independent experiments. TSB, tryptic soy broth.