FIG 7.

Antibacterial effect of L-161,982 on MRSA enhances survival in a mouse model of C. albicans-S. aureus polymicrobial intra-abdominal infection. The effect of inhibition of EP₄ receptor signaling on survival is shown. Mice received either vehicle or an EP₄ receptor antagonist at a dose of 10 mg/kg by i.p. injection, as indicated in Materials and Methods. Mortality compared to that in the control groups was assessed using the Kaplan-Meier test (***, P < 0.001; n = 20/group). The data shown are representative of those from three replicate experiments.