TABLE 1.
Characteristics of KPC-2-producing Enterobacteriaceae isolates
| Species and isolate | Hospital departmenta | Isolation date | Clinical material | STb | Size of blaKPC plasmid (kb) | Type of plasmid sequence (replicon) | MIC (μg/ml) ofc: |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ctx | Caz | Fep | Atm | Imp | Mem | Etp | Gen | Amk | Tob | Sxt | Cip | Col | Tgc | Fos | |||||||
| C. freundii | |||||||||||||||||||||
| Cfr-27569 | ICU | 11/2014 | Urine | 18 | 46.826 | A (IncR) | >8 | >16 | >16 | >16 | 16 | >16 | >4 | >32 | 16 | >8 | >64 | >8 | 0.25 | 0.25 | ≤2 |
| Cfr-31260 | ICU | 09/2015 | Urine | 18 | 46.826 | A (IncR) | >8 | >16 | >16 | >16 | >32 | >16 | >4 | >32 | 32 | >8 | >64 | >8 | 0.12 | 0.25 | ≤2 |
| Cfr-31816 | ICU | 10/2015 | Urine | 18 | 46.826 | A (IncR) | >8 | >16 | >16 | >16 | >32 | 16 | 4 | >32 | >32 | >8 | >64 | >8 | 0.12 | 0.12 | ≤2 |
| Cfr-33038d | ICU | 11/2015 | Rectal swab | 18 | 46.826 | A (IncR) | >8 | >16 | >16 | >16 | >32 | >16 | >4 | >32 | 16 | >8 | >64 | >8 | 4 | 1 | 8 |
| Cfr-33795 | ICU | 04/2016 | Urine | 142 | 30.051 | C (IncP6) | >8 | >16 | >16 | >16 | 4 | 8 | 4 | 4 | 32 | >8 | >64 | 4 | 0.12 | 0.5 | ≤2 |
| Cfr-36049 | ICU | 09/2016 | Wounds | 87 | 81.348 | B (IncR and IncN3) | >8 | >16 | >16 | >16 | 8 | 8 | >4 | 1 | 16 | >8 | 1 | ≤0.06 | 1 | 0.06 | ≤2 |
| Cfr-36808 | HD | 11/2016 | Rectal swab | 18 | 46.826 | A (IncR) | >8 | 16 | 16 | >16 | 12 | 16 | >4 | >32 | >32 | >8 | >64 | >8 | 0.25 | 0.12 | ≤2 |
| K. pneumoniae | |||||||||||||||||||||
| Kpn-35786d | ICU | 09/2016 | Catheter | 11 | 46.826 | A (IncR) | >8 | >16 | >16 | >16 | >32 | >16 | 2 | >32 | 16 | >8 | >64 | >8 | >16 | 1 | >128 |
| E. coli | |||||||||||||||||||||
| Eco-36682d | ICU | 11/2016 | Catheter | 216 | 81.348 | B (IncR and IncN3) | 4 | 4 | 2 | >16 | 32 | 4 | 2 | 2 | >32 | >8 | 0.06 | ≤0.06 | ≤0.06 | 0.25 | ≤2 |
| M. morganii | |||||||||||||||||||||
| Mmo-37590d | ICU | 12/2016 | Urine | NA | 30.051 | C (IncP6) | >8 | 8 | >16 | >16 | 16 | 8 | 1 | 2 | 32 | 8 | >64 | 8 | >16 | 0.5 | >128 |
a
ICU, intensive care unit; HD, hematology department.
b
ST, sequence type; NA, not applicable.
c
Ctx, cefotaxime; Caz, ceftazidime; Fep, cefepime; Atm, aztreonam; Imp, imipenem; Mem, meropenem; Etp, ertapenem; Gen, gentamicin; Amk, amikacin; Tob, tobramycin; Sxt, trimethoprim-sulfamethoxazole; Cip, ciprofloxacin; Col, colistin; Tgc, tigecycline; Fos, fosfomycin.
d
KPC-2-like-producing isolates recovered from the same patient.