TABLE 1.

Pharmacokinetic profile of the deoxycholate form of AmB and AmBisome in uninfected and L. major-infected mice after a single i.v. 1-mg/kg dose^a

PK parameter (unit)	Value(s) for:
	DAmB		LAmB
	Uninfected	Infected	Uninfected	Infected
Cmax (μg/ml)	1.1	1.0	11.1	8.2
AUC (h · μg/ml)	21.5	30.2	62.7	71.0
Clearance (ml/h/kg)	29.6	18.9	14.2	13.5
t1/2 (h)	36.1	39.7	10.7	8.5
V (ml/kg)	1458	1075	225	143

^aValues for pharmacokinetic parameters are calculated from the plasma PK profiles seen in Fig. 1a and b.