TABLE 2.

Skin distribution of the deoxycholate form of AmB and AmBisome in uninfected and L. major-infected mice after a single i.v. 1-mg/kg dose^a

Skin site	AUC0.5–48 value for:
	DAmB		LAmB
	Uninfected	Infected	Uninfected	Infected
Rump (lesion site)	1,586 ± 495	6,035 ± 273	863 ± 365	5,270 ± 1,003
Back (control site)	1,269 ± 190	710 ± 194	573 ± 142	915 ± 312
Rump-to-back ratio	1.3	8.5	1.5	5.8

^aAUC_0.5–48 values are calculated from skin PK profiles shown in Fig. 1c, d, e, and f.