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Paradoxical survival of wild-type E. coli is associated with high concentrations of nalidixic acid. Exponentially growing cultures of wild-type E. coli (strain 3505) were treated with nalidixic acid (Nal) at the indicated concentrations for 1 h (squares), 2 h (circles), or 3 h (triangles). Percentage of cells recovered was determined relative to CFU at the time of drug addition. Data are from at least three independent experiments; error bars represent standard errors of the mean.
