TABLE 1.
Population PK parameter estimates, precisions of estimates (SD), and between-subject variability determined using the final two-compartment model with allometric scaling of TBWa
| PK parameter | Mean value | Median value | SD | Between-subject variability (% CV) |
|---|---|---|---|---|
| Vc (liters) | 33.77 | 31.49 | 15.21 | 45.03 |
| CL (liter/h) | 2.63 | 2.17 | 1.41 | 53.63 |
| Q (liter/h) | 2.32 | 2.30 | 1.33 | 57.41 |
| Vp (liters) | 78.20 | 100.00 | 37.46 | 47.90 |
a
Abbreviations: CV, coefficient of variation; Vc, volume of distribution in the central compartment; CL, total body clearance; Q, intercompartmental flow; Vp, volume of distribution in the peripheral compartment.