TABLE 1.

Activity of dalbavancin and comparator antimicrobial agents tested against S. aureus isolates with decreased susceptibility to glycopeptides, daptomycin, and/or linezolid from U.S. medical centers

Organism subset and antimicrobial agent	MIC50 (mg/liter)	MIC90 (mg/liter)	MIC range (mg/liter)	CLSIa		EUCASTa
				%S	%R	%S	%R
Vancomycin MIC ≥2 mg/liter (n = 1,141)
Dalbavancin	0.06	0.12	≤0.03 to 0.5	99.3b		95.5	4.5
Daptomycin	0.5	1	≤0.12 to 4	96.8		96.8	3.2
Vancomycin	2	2	2 to 4	99.3	0.0	9.3	0.7
Teicoplanin	≤2	≤2	≤2 to 16	99.9	0.0	93.5	6.5
Linezolid	1	2	≤0.12 to >8	99.6	0.4	99.6	0.4
Oxacillin	>2	>2	≤0.25 to >2	26.9	73.1	26.9	73.1
Daptomycin nonsusceptible (n = 48)
Dalbavancin	0.06	0.12	≤0.03 to 0.5	95.8b		91.7	8.3
Daptomycin	2	4	2 to 4	0.0		0.0	100.0
Vancomycin	2	2	1 to 4	95.8	0.0	95.8	4.2
Teicoplanin	≤2	4	≤2 to 16	97.9	0.0	87.5	12.5
Linezolid	1	2	0.5 to 4	100.0	0.0	100.0	0.0
Oxacillin	>2	>2	≤0.25 to >2	12.5	87.5	12.5	87.5
Telavancin MIC ≥0.12 mg/liter (n = 52)c
Dalbavancin	0.06	0.25	≤0.03 to 0.5	90.4b		84.6	15.4
Daptomycin	0.5	1	0.25 to 2	96.2		96.2	3.8
Vancomycin	1	2	1 to 4	98.1	0.0	98.1	1.9
Telavancin	0.12	0.12	0.12 to 0.25	96.2		96.2	3.8
Teicoplanin	≤2	4	≤2 to 16	98.1	0.0	76.9	23.1
Linezolid	1	1	0.25 to 2	100.0	0.0	100.0	0.0
Oxacillin	>2	>2	≤0.25 to >2	34.6	65.4	34.6	65.4
Teicoplanin MIC ≥4 mg/liter (n = 143)
Dalbavancin	0.06	0.25	≤0.03 to 0.5	95.1b		83.9	16.1
Daptomycin	0.5	1	0.12 to 4	95.8		95.8	4.2
Vancomycin	2	2	0.5 to 4	97.9	0.0	97.9	2.1
Teicoplanin	4	8	4 to 16	99.3	0.0	0.0	100.0
Linezolid	1	2	0.25 to 4	100.0	0.0	100.0	0.0
Oxacillin	>2	>2	≤0.25 to >2	26.6	73.4	26.6	73.4
Linezolid resistant (n = 25)
Dalbavancin	0.06	0.06	≤0.03 to 0.12	100.0b		100.0	0.0
Daptomycin	0.5	0.5	0.25 to 0.5	100.0		100.0	0.0
Vancomycin	1	2	0.5 to 2	100.0	0.0	100.0	0.0
Teicoplanin	≤2	≤2	≤2 to ≤2	100.0	0.0	100.0	0.0
Linezolid	8	>8	8 to >8	0.0	100.0	0.0	100.0
Oxacillin	>2	>2	≤0.25 to >2	4.0	96.0	4.0	96.0

^aCriteria as published by CLSI (11) and EUCAST (12). S, susceptible; R, resistant.

^bBreakpoints from FDA package insert, i.e., susceptible at ≤0.25 mg/liter (13).

^cTelavancin was only tested against isolates collected in 2011 to 2016.