TABLE 3.
Observed and model-simulated fAUC/MIC targets in plasma associated with bacteriostasis and 1-log10 kill against three strains of P. aeruginosa in neutropenic infected micea
| Kill level |
fAUC/MIC |
|||||
|---|---|---|---|---|---|---|
| ATCC 27853 |
PAO1 |
FADDI-PA022 |
||||
| Observed value | Simulated value | Observed value | Simulated value | Observed value | Simulated value | |
| Stasis | 2.99 (2.47–4.17) | 3.62 (2.00–4.10) | 3.29 (2.90–3.91) | 3.48 (1.52–10.4) | 2.15 (1.90–2.45) | 2.85 (0.80–4.12) |
| 1-log10 kill | ND | ND | 4.68 (3.48–5.23) | 5.55 (1.99–14.82) | 2.60 (2.25–3.50) | 4.36 (0.88–4.55) |
a
Data for observed values are from reference 14. Values in parentheses represent the 10th to 90th percentile range generated from the Monte Carlo simulation. ND, not determined.