TABLE 3.
TNF-α and IL-6 levels in the blood of mice infected with C. glabrata strains
| Strain | Cytokine concna (pg/ml) |
|
|---|---|---|
| TNF-α | IL-6 | |
| Control (PBS) | UD | 0.3 ± 0.2 |
| Wild type | 39.8 ± 7.5a,b,c | 411.0 ± 48.1g,h,i |
| ada2 mutant (YSJ4) | 130.3 ± 12.9a,d,e | 410.3 ± 85.8g,j,k |
| ada2 mutant (YSJ39) | 101.8 ± 16.9b,d,f | 336.6 ± 100.6h,j,l |
| ada2::ADA2 mutant (YSJ49) | 10.2 ± 1.6c,e,f | 216.6 ± 45.5i,k,l |
a
Data represent the mean ± standard deviation. In the statistical analyses, P values were determined by an unpaired t test. The P values between two measurements with the same superscript letter were as follows: a, P = 0.0008; b, P = 0.018; c, P = 0.0037; d, P = 0.218; e, P = <0.0001; f, P = 0.0007; g, P = 0.994; h, P = 0.560; i, P = 0.022; j, P = 0.592; k, P = 0.081; l, P = 0.308. UD, undetected.