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. 2018 Feb 20;11:37. doi: 10.3389/fnmol.2018.00037

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Copyright © 2018 Pai, Sharma, Huang, Loganathan, Lin, Hsu, Phasuk and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of the Atf3^-/- mice. No significant difference (p > 0.05) was recorded between Atf3^-/- mice and their wild-type littermates in morphology (A), body weight (WT: n = 7; Atf3^+/-: n = 8; Atf3^-/-: n = 9) (B), locomotor activity during the daytime (WT: n = 9; Atf3^+/-: n = 10; Atf3^-/-: n = 10) (C) and nighttime (WT: n = 9; Atf3^+/-: n = 9; Atf3^-/-: n = 9) (D), t`1q1ail flick test (WT: n = 7; ATF3^+/-: n = 8; Atf3^-/-: n = 7) (E), pin prick test (WT: n = 6; Atf3^+/-: n = 6; Atf3^-/-: n = 8) (F). Genotyping with PCR was performed for each mouse used for behavioral experiments (G). Neither ATF3 transcript (H) nor ATF3 protein (I) was detected in the hippocampus.