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. 2018 Feb 20;9:20. doi: 10.3389/fendo.2018.00020

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Copyright © 2018 Kayani, Mohammed and Mohiaddin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothesized model of normal (left) and cystic fibrosis (CF) (right) beta cells. The defect in CFTR in the CF beta cell impairs both chloride efflux and vesicle release, impairing insulin secretion, giving an insulinopenic state.