Table 2.
Physical properties of glimepiride transdermal patches
| Code | Appearancea | Thicknessa (µm) ±SD | Weighta (mg/1.5 cm2) | Folding endurancea ±SD | Moisture content (%)b | Moisture uptake (%)b | Swelling index | Erosion (%) | WVP (mg·Pa−1· cm−1·hr−1) | WVTR g/m2·hr | Drug content (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 | Ss, F, NB, T, St, H | 710±2.21 | 32.3±0.021 | >200 | 4.89 | 7.16 | 1.012 | 4.41 | 6.92×10−5 | 4.51×10−5 | 99.45±0.021 |
| G2 | Ss, F, NB, T, St, H | 723±1.42 | 33.4±0.032 | >200 | 4.82 | 6.19 | 1.119 | 5.61 | 7.41×10−5 | 4.21×10−5 | 97.87±0.015 |
| G3 | Ss, F, NB, T, St, H 713±1.92 | 32.8±0.028 | >200 | 4.71 | 6.11 | 0.991 | 4.89 | 6.86×10−5 | 4.44×10−5 | 98.84±0.0213 | |
| G4 | Ss, F, NB, T, St, H | 725±1.54 | 32.5±0.026 | >200 | 4.62 | 5.66 | 1.218 | 4.87 | 7.18×10−5 | 3.89×10−5 | 101.98±0.004 |
| G5 | Ss, F, NB, T, St, H | 714±1.73 | 33.7±0.018 | >200 | 4.39 | 5.83 | 0.839 | 5.5 | 8.12×10−5 | 3.8×10−5 | 99.09±0.013 |
| G6 | Ss, F, NB, T, St, H | 724±2.16 | 33.8±0.022 | >200 | 3.78 | 5.37 | 0.967 | 6.12 | 6.79×10−5 | 3.78×10−5 | 98.27±0.015 |
| G7 | Ss, F, NB, T, St, H | 720±1.85 | 32.9±0.018 | >200 | 3.55 | 4.93 | 1.211 | 5.17 | 7.71×10−5 | 3.32×10−5 | 101.11±0.018 |
| G8 | Ss, F, NB, T, St, H | 723±1.34 | 33.5±0.028 | >200 | 3.45 | 4.71 | 1.337 | 6.68 | 6.98×10−5 | 3.21×10−5 | 97.25±0.013 |
| G9 | Ss, F, NB, T, St, H | 724±1.82 | 33.7±0.032 | >200 | 3.39 | 4.47 | 1.421 | 5.87 | 7.23×10−5 | 3.11×10−5 | 98.24±0.016 |
Notes:
a
Each value is the mean ± SD (n=7);
b
each value is the mean ± SD (n=3). Folding endurance refers to the number of times the film was folded.
Abbreviations: Ss, surface smoothness; F, flexibility; NB, non-brittle; T, transparent; St, sticky; H, homogenous; SD, standard deviation; WVP, water vapor permeability; WVTR, water vapor transmission rate.