Table 3.
Release kinetics of glimepiride from matrix patches having different ratios of polymers
| Formulation code | Polymer ratios RL 100:RS 100 | Zero order (r2) | First order (r2) | Higuchi (r2) | Higuchi (KH) | Korsmeyer–Peppas (r2) | Korsmeyer–Peppas (n) |
|---|---|---|---|---|---|---|---|
| G1 | 9:1 | 0.7967 | 0.8821 | 0.9606 | 7.225 | 0.9733 | 0.587 |
| G2 | 8:2 | 0.8648 | 0.9453 | 0.9580 | 8.573 | 0.9860 | 0.638 |
| G3 | 7:3 | 0.8927 | 0.9778 | 0.9450 | 10.634 | 0.9852 | 0.672 |
| G4 | 6:4 | 0.8342 | 0.9187 | 0.9683 | 8.039 | 0.9864 | 0.607 |
| G5 | 5:5 | 0.8292 | 0.8985 | 0.9826 | 6.631 | 0.9964 | 0.592 |
| G6 | 4:6 | 0.8610 | 0.9177 | 0.9666 | 6.203 | 0.9906 | 0.627 |
| G7 | 3:7 | 0.9185 | 0.9546 | 0.9409 | 5.521 | 0.9906 | 0.698 |
| G8 | 2:8 | 0.9211 | 0.9540 | 0.9360 | 5.232 | 0.9886 | 0.705 |
| G9 | 1:9 | 0.9193 | 0.9506 | 0.9315 | 4.738 | 0.9857 | 0.709 |