Table 4.

Release kinetics of glimepiride from matrix patches having different permeation enhancers

Formulation	Zero order (r2)	First order (r2)	Higuchi (r2)	Higuchi (KH)	Korsmeyer–Peppas (r2)	Korsmeyer–Peppas (n)
IPM 2%	0.9591	0.8838	0.9881	13.259	0.9817	0.813
IPM 5%	0.9564	0.8990	0.9910	14.552	0.9866	0.788
IPM 10%	0.9440	0.8940	0.9801	16.347	0.9777	0.779
Span® 80 2%	0.8113	0.9553	0.9351	10.761	0.9717	0.601
Span® 80 5%	0.9149	0.9307	0.9856	10.825	0.9839	0.706
Span® 80 10%	0.9216	0.9293	0.9904	11.441	0.9857	0.714
Tween® 20 2%	0.9251	0.9015	0.9845	12.390	0.9715	0.747
Tween® 20 5%	0.9768	0.8864	0.9935	12.240	0.9933	0.835
Tween® 20 10%	0.9450	0.8931	0.9899	10.779	0.9779	0.781
Eucalyptus oil 2%	0.9290	0.9278	0.9940	11.737	0.9879	0.723
Eucalyptus oil 5%	0.9581	0.9101	0.9979	11.220	0.9923	0.776
Eucalyptus oil 10%	0.9757	0.8632	0.9885	11.279	0.9855	0.869
Limonene 2%	0.9313	0.9100	0.9852	9.731	0.9793	0.745
Limonene 5%	0.9289	0.9298	0.9894	10.548	0.9889	0.720
Limonene 10%	0.9333	0.9136	0.9896	10.951	0.9820	0.743
Without enhancer	0.8712	0.9537	0.9629	9.949	0.9848	0.647

Abbreviation: IPM, isopropyl myristate.