Table 5.
Skin permeation parameters of glimepiride across rabbit skin from patches containing different concentrations of enhancers
| Formulation | Cumulative drug permeated Q24 (µg/1.5 cm2) |
Permeation flux J (µg/cm2/hr) |
Enhancement factor |
|---|---|---|---|
| IPM 2% | 1,189.44 | 49.986 | 5.55 |
| IPM 5% | 1,085.23 | 39.345 | 4.37 |
| IPM 10% | 1,322.282 | 51.763 | 5.75 |
| Span® 80 2% | 990.7972 | 37.731 | 4.19 |
| Span® 80 5% | 1,016.39 | 36.497 | 4.05 |
| Span® 80 10% | 1,073.668 | 39.722 | 4.41 |
| Tween® 20 2% | 946.9243 | 30.394 | 3.37 |
| Tween® 20 5% | 967.642 | 31.152 | 3.46 |
| Tween® 20 10% | 1,056.607 | 36.021 | 4 |
| Eucalyptus oil 2% | 1,056.607 | 38.658 | 4.29 |
| Eucalyptus oil 5% | 1,129.728 | 43.131 | 4.79 |
| Eucalyptus oil 10% | 1,160.195 | 42.931 | 4.77 |
| Limonene 2% | 744.6213 | 23.501 | 2.61 |
| Limonene 5% | 828.7111 | 27.682 | 3.07 |
| Limonene 10% | 904.27 | 31.955 | 3.55 |
| Without enhancer | 213 | 9 | 1 |
Abbreviations: IPM, isopropyl myristate; Q24, cumulative drug permeated in 24 hours.