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. 2018 Feb 20;11:45. doi: 10.3389/fnmol.2018.00045

Figure 5.

Figure 5

Administration of a caspase-3 inhibitor before ethanol treatment in P7 mice rescues persistent spatial and social recognition memory (SRM) deficits in adulthood. (A,B) The spatial working memory was determined using the Y-maze in adult mice treated with saline (S), ethanol (E), S + Q-VD-OPh, or E + Q-VD-OPh at P7. The discrimination ratio [preference for the novel arm over the familiar other arm (Novel/Novel + Other)] for arms entries (A) and dwell time (time spent in each arm) (B) of S, E, S + Q-VD-OPh and E + Q-VD-OPh -treated mice, 24 h after the first encounter with the partially opened maze. The dashed line denotes chance performance (0.5). (C–E) The spontaneous alternation memory of adult mice treated with saline (S), ethanol (E), S + Q-VD-OPh, or E + Q-VD-OPh at P7 was evaluated using the Y-maze. (C) The number of arm entries by mice in all the treatment groups. (D) The time spent in each arm by mice in all the treatment groups. (E) The spontaneous alternation performance by mice in all the treatment groups. (F) The percent of social investigation is shown for P7 S, E, S + Q-VD-OPh and E + Q-VD-OPh -treated adult mice, 24 h after the first encounter with the same juvenile mice. (*p < 0.01 vs. saline; $p < 0.05 vs. saline; #p < 0.05 vs. ethanol, n = 8 mice/group). Error bars, SEM (two-way ANOVA with Bonferroni’s post hoc test).