Table 1.

Comparison of H3K4me3-related GO-terms in β-trained monocytes and monocytes of SLE patients.

	Go-term	β-Glucan-induced trained immunity	SLE
		p-Value	p-Value
M1	Sugar binding	3.9E−2	0.72
M2	Carboxylic acid metabolic process	7.9E−5	4.5E−2
	Cellular ketone metabolic process	1.3E−4	0.32
	Oxidoreductase	1.4E−3	4.3E−2
	Lipid metabolic process	5.4E−6	3.2E−3
M3	Signal transducer activity	2.4E−3	3.7E−2
	Receptor activity	2.1E−2	1.2E−2
M4	Cofactor binding	3.5E−3	0.16
M5	Immune response	3.00E−19	3.7E−2
	Response to wounding	5.00E−17	1.3E−2
	Chemotaxis	5.2E−7	0.79
	Cytokine activity	8.00E−12	5.3E−2
	Chemokine activity	3.7E−9	9.3E−2

H3K4me3 modulations were related to gene promoter site. Related GO-terms of the major epigenetically modulated promoter sites in in vitro β-glucan-trained monocytes, defined as M clusters (10), were compared with the same GO-terms in monocytes of SLE patients (78) and adjusted p-values are shown.