Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 20;12:85. doi: 10.3389/fnins.2018.00085

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Noack and Calegari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Possible uses of the CRISPR-dCas13 (gray) system for epitranscriptome editing of N6-methyladensosine (m6A, top) or 5-methylcytosine (5mC, bottom). Top: Fusing dCas13 together with METTL3 (green) or FTO (white) may allow the site and transcript specific methylation (green) or demethylation (white) of mRNA, respectively resulting in m6A-mediated changes in translation or RNA stability (red or green arrows). Bottom: methylation of cytosine (red) or oxidation of 5mC (blue) of cytosine can be triggered by dCas13 fusion to NSUN2 (red) or TET (blue), respectively potentially resulting in a decreased (red arrow, left) or increased (green arrow, right) translation.