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. 2018 Feb 20;11:28. doi: 10.3389/fnmol.2018.00028

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Copyright © 2018 Vogelgesang, Niebert, Bischoff, Hülsmann and Manzke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plethysmographic in vivo recordings. (A) Plethysmographic in vivo recordings of wild type (WT; n = 9), Htr5b^−/− (n = 7), Mecp2^−/y (n = 10) and Mecp2^−/y;Htr5b^−/− (n = 11) mice at postnatal day 40 (P40). Recordings revealed improved breathing in Mecp2^−/y;Htr5b^−/− mice, which was expressed by the (B) reduction of long (>1 s) apneas, (C) respiratory frequency and (D) irregularity score (IS). Corresponding bar diagrams represent the mean value and standard error of the mean (SEM). Asterisks indicate significance (*P < 0.05, **P < 0.01; Kruskal-Wallis test with Dunn’s multiple comparisons).