Table S1.

Characteristics of the studies as per the PICOS strategy

PICOS
Study	Participants	Interventions	Comparisons	Outcomes	Study design
Sali et al1	Asymptomatic, age 54–65 years	1) R-CTC 2) F-CTC 3) FIT	Colonoscopy	–Rate of participation in the different procedures –Rate of detection of polyps/CRC	RCT
Stoop et al2	Asymptomatic, age 50–75 years	CT colonography	Colonoscopy	–Rate of participation in the different procedures –Rate of detection of polyps/CRC	RCT
Scott et al3	Asymptomatic, age 50–70 years	CT colonography	Colonoscopy	–Rate of participation in the different procedures –Rate of detection of polyps/CRC	RCT

Abbreviations: CT, computed tomography; CRC, colorectal cancer; F-CTC, full-preparation computed tomography colonography; FIT, fecal immunochemical test; PICOS, patient, intervention, comparison intervention, outcome, study design; R-CTC, reduced-preparation computed tomography colonography; RCTs, randomized clinical trials.