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. 2018 Feb 20;12:90. doi: 10.3389/fnins.2018.00090

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Copyright © 2018 Lu, Zhang, Zhao, Yang, Pan, Li, Liu, Bai, Gao and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical staining of tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and striatum. (A) Illustration of toxicity of MPTP on TH in both SNpc and striatum at the first day after the last treatment. (B) MPTP administration induced a significant decrease (64%) number of TH-positive neurons in SNpc of PD group compared with control group (3,213 ± 348 vs. 1,142 ± 122). Bar represented means ± SD of three mice per group (^***p < 0.001).