Table S1.
The KEGG pathway annotation of the published mutated genes and that of the proband patient
| Term | Count | % | P-value | Benjamini | |
|---|---|---|---|---|---|
| Public | PI3K–Akt signaling pathway | 3 | 25 | 3.30E–02 | 7.80E–01 |
| Pathways in cancer | 3 | 25 | 4.20E–02 | 6.20E–01 | |
| Endometrial cancer | 2 | 16.7 | 4.40E–02 | 5.00E–01 | |
| Fanconi anemia pathway | 2 | 16.7 | 4.50E–02 | 4.10E–01 | |
| Prostate cancer | 2 | 16.7 | 7.40E–02 | 5.10E–01 | |
| Son | Transcriptional misregulation in cancer | 4 | 22.2 | 5.20E–03 | 3.00E–01 |
| PI3K–Akt signaling pathway | 5 | 27.8 | 5.40E–03 | 1.70E–01 | |
| Non-small-cell lung cancer | 3 | 16.7 | 6.30E–03 | 1.40E–01 | |
| Central carbon metabolism in cancer | 3 | 16.7 | 8.20E–03 | 1.30E–01 | |
| Base excision repair | 2 | 11.1 | 6.90E–02 | 6.30E–01 | |
| Bladder cancer | 2 | 11.1 | 8.50E–02 | 6.50E–01 |
Abbreviation: PI3K, phosphoinositide 3-kinase.