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. 2018 Feb 20;9:257. doi: 10.3389/fmicb.2018.00257

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Copyright © 2018 Hao, Cui and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of S. thermophilus CRISPR3 and S. pyogenes type II CRISPR-Cas loci and their homology comparison. The spacers and repeat sequences are represented by colored rhombi and black columns, respectively. The homology percentage between four Cas protein genes and repeat sequences are indicated in the gray shading. (S. thermophilus ASCC 1275 NCBI Reference Sequence: NZ_CP006819.1 and S. pyogenes NCBI Reference Sequence: NC_007296.1).