Table 2.

Chronic effects of A-769662 on plasma metabolic variables in chow-fed mice and HFD-fed mice.

Parameters	Chow-Veh	Chow-A-769662	HFD-Veh	HFD-A-769662
TC (mM)	3.58 ± 0.37	3.64 ± 0.47	8.04 ± 0.52	5.12 ± 0.56***
LDL-C (mM)	0.66 ± 0.08	0.57 ± 0.03	1.66 ± 0.11	1.21 ± 0.16*
HDL-C (mM)	0.44 ± 0.04	0.45 ± 0.07	0.58 ± 0.04	0.54 ± 0.07
LDL-C/HDL-C	1.47 ± 0.08	1.29 ± 0.24	3.09 ± 0.37	2.70 ± 0.45
TG (mM)	0.50 ± 0.04	0.53 ± 0.06	0.46 ± 0.02	0.34 ± 0.03**
NEFA (mEq/L)	0.62 ± 0.06	0.64 ± 0.09	0.52 ± 0.05	0.45 ± 0.03
Insulin (ng/ml)	1.51 ± 0.13	1.67 ± 0.04	4.64 ± 0.79	2.74 ± 0.32*
Leptin (ng/ml)	1.99 ± 0.56	2.10 ± 0.33	68.42 ± 7.07	30.31 ± 5.05***
Irisin (ng/ml)	108.85 ± 6.21	102.52 ± 4.06	109.04 ± 3.28	106.59 ± 4.40

Values are expressed as the means ± SEM. n = 6–10. Student's t-test.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 compared with the corresponding vehicle group.