Fig 5. Canonical pathway analysis of RAW 264.7 macrophages revealed the eukaryotic initiation factor 2 (eIF2) signaling pathway among the topmost canonical pathways enriched upon treatment with ethanol and LPS.

Differential protein expression is denoted as red (upregulated) and green (downregulated). The canonical pathways were generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis/) (37).