Table 2.

Genome-wide studies of environmentally-induced gene regulation.

Year	Species	Type of expression analysis	Stimuli/Experience	Duration	Tissue	Reference
2001	Rat	Microarray	Running wheel	3 weeks	Hippocampus	Tong et al., 2001
2002	Rat	Microarray	Resistance running wheel (100 g)	3 days, 1 week, 4 weeks	Hippocampus	Molteni et al., 2002
2008	Mouse	Microarray	Running wheel	16 months	Hippocampus	Stranahan et al., 2008
2011	Rat	Microarray	Running wheel	2 weeks	Hippocampus	Funk et al., 2011
2011	Mouse	Microarray	Running wheel	8 weeks	Hippocampus	Kohman et al., 2011
2013	Mouse	Microarray	Running wheel 3 days per week	6 months	Hippocampus	Alvarez-Lopez et al., 2012
2014	Rat	Microarray	Resistance running wheel (30% body weight)	4 weeks	Hippocampus	Lee et al., 2014
			Running wheel (no resistance
2015	Rat	Microarray	Forced running on treadmill (mild exercise) 1 hour per day	6 weeks	Hippocampus	Inoue et al., 2015
			Forced running on treadmill (intense exercise) 1 hour per day
2015	Mouse	Microarray	Running wheel	3 days	Dentate gyrus	Guerrieri et al., 2015
				1 week
				2 weeks
2003	Rat	Growth factor chip	ECS: 1 shock		Hippocampus	Newton et al., 2003
2004	Rat	Microarray	ECS: 1 shock per day	10 days	Hippocampus	Altar et al., 2004
2006	Rat	Microarray	ECS: 1 shock per day	10 days	DG granule cell layer	Ploski et al., 2006
2007	Rat	Microarray	ECS: 4 shocks per day	2 days	Prefrontal cortex	Conti et al., 2007
					Frontal cortex
					Amygdala
					Hypothalamus
					Hippocampus
					Dorsal raphe
					Locus coeruleus
2008	Rat	CREB ChIP + microarray	ECS: 1 shock	1 day	Frontal cortex, hippocampus, striatum	Tanis et al., 2008
2011	Mouse	Methyl-sensitive cut counting + sequencing	ECS: 1 shock	1 day	DG tissue	Guo et al., 2011
2013	Rat	miRNA microarray	ECS: 1 shock per day	10 days	Hippocampus	O’Connor et al., 2013
2000	Mouse	Microarray	6 hours daily exposure; various toys, wooden blocks, running wheel, and small houses; rearranged every half-day	3–6 hours	Cortex	Rampon et al., 2000
				2–14 days
2004	Rat	Microarray	24 hours daily; spacious 2-level glass terraria with nesting material, plastic stairs, hemp ropes, pipes, box of soil, wooden blocks, other colored objects; rearranged twice per week	2 weeks	Hippocampus	Keyvani et al., 2004
2005	Mouse	Microarray	3 hours per day for first month, 3 sessions per week for next 4 months; large cages with running wheels, colored tunnels, toys, and chewable material	5 months	Hippocampus	Lazarov et al., 2005
2016	Mouse	Single-nuclei RNA-seq	One 15-minute session; large cages with huts and tunnels	One time	Individual DG neurons	Lacar et al., 2016

This table summarizes published genome-wide studies discussed in section 4.